📄 Category

developmental biology

274 papers

Robust self-organization of livestock pluripotent stem cells into post-gastrulation embryo models with advanced neuronal and mesodermal structures

This study establishes robust stem cell-based embryo models for sheep and pigs that successfully recapitulate post-gastrulation development, including the formation of complex neuronal and mesodermal structures like somites and neural tubes, thereby filling a critical gap in ungulate developmental biology and enabling comparative research across mammalian species.

Hauser, M., Berkowicz, P., Namestnikov, M. + 3 more2026-03-05📄 developmental biology

From Variability to Synchrony: Non-linear Development of Auditory Neural Responses During the First Year of Life

This longitudinal high-density EEG study of 69 infants reveals that auditory neural maturation during the first year of life follows a non-linear trajectory characterized by increasing response strength and reduced variability, alongside a dynamic shift in phase synchronization that initially improves temporal alignment before decreasing to facilitate more differentiated brain activity.

Reisenberger, E., Schabus, M., Florea, C. + 7 more2026-03-04📄 developmental biology

A cell atlas of the developing human outflow tract of the heart and its adult aortic valve derivatives

This study presents a comprehensive cell atlas of the developing human heart outflow tract and its adult aortic valve derivatives, revealing persistent embryonic signatures and identifying GATA6 as a key regulator to elucidate the molecular mechanisms underlying congenital heart defects and inform regenerative medicine.

Leshem, R., Murtuza Baker, S., Mallen, J. + 8 more2026-03-03📄 developmental biology

Exploration of the screening and regulatory mechanisms of biomarkers related to ac4C modification in laryngeal squamous cell carcinoma patients based on single-cell analysis and machine learning

This study integrates single-cell analysis and machine learning to identify seven ac4C-related prognostic genes in laryngeal squamous cell carcinoma that modulate the tumor immune microenvironment and serve as potential therapeutic targets.

Wang, L., Gong, X., Chen, D. + 6 more2026-03-03📄 developmental biology

Early life stress of maternal deprivation and peer-rearing jeopardize mesoprefrontal and mesolimbic dopamine receptors in the rhesus monkey

This study demonstrates that early-life maternal deprivation in rhesus monkeys leads to altered dopamine receptor densities in specific prefrontal and claustral brain regions compared to peer-rearing, suggesting a hypodopaminergic prefrontal-claustral ecophenotype that underlies the cognitive, affective, and social impairments observed in nursery-reared monkeys.

Seraphin, S. B., Sanchez, M. M.2026-03-03📄 developmental biology

Gastruloids reveal alternative morphogenetic routes for body axiselongation with distinct cytoskeletal dependencies

Using gastruloids, this study demonstrates that substrate availability dictates distinct morphogenetic strategies for mammalian body-axis elongation, where free-floating conditions rely on cell-cell interactions while laminin adhesion triggers collective migration dependent on formin activity and focal adhesions, revealing that mechanical cues can switch cytoskeletal requirements without altering transcriptional programs.

Serrano Najera, G., Delahaye, A., Steventon, B.2026-03-02📄 developmental biology

A Novel 3D Visualization Method in Mice Identifies the Periportal Lamellar Complex (PLC) as a Key Regulator of Hepatic Ductal and Neuronal Branching Morphogenesis

This study introduces a novel high-resolution 3D imaging platform combining metallic compound nanoparticle perfusion and Liver-CUBIC tissue clearing to identify the Periportal Lamellar Complex (PLC) as a previously unrecognized, low-permeability endothelial structure that serves as a critical scaffold guiding bile duct and neuronal branching morphogenesis during liver fibrosis.

Xu, T., Cao, F., Zhou, R. + 7 more2026-03-02📄 developmental biology

FuChi: A cell cycle biosensor for investigating cell-cycle kinetics during avian development.

This paper introduces FuChi, a novel transgenic chicken line equipped with an optimized multicistronic Fucci biosensor that enables precise, real-time tracking of all cell cycle phases in live embryos, thereby revealing critical proliferation dynamics during avian development and establishing a superior in vivo model for studying cell-cycle kinetics.

Sudderick, Z. R., Briggs, T., Mubarak, S. + 21 more2026-03-02📄 developmental biology

Cone photoreceptor ablation in microglia-deficient larval zebrafish retina elicits a regenerative response alongside a compensatory immune cell response

This study demonstrates that while cone photoreceptor ablation in microglia-deficient larval zebrafish triggers a compensatory immune response and only modestly affects Müller glia proliferation and cone regeneration, the presence of these alternative immune cells limits definitive conclusions about microglia's specific role in retinal regeneration.

Rumford, J. E., Farre, A. A., Mai, J. + 4 more2026-03-01📄 developmental biology

Genome wide transcriptional changes underlie gradual and recurrent adaptation to protein malnutrition in zebrafish

This study demonstrates that zebrafish can gradually overcome a heritable defect in intestinal protein absorption through recurrent, genome-wide transcriptional changes that hyperactivate endocytic components in specialized enterocytes while simultaneously recalibrating immune responses to ensure survival despite protein malnutrition.

Wang, S., Childers, L., Martinez, F. + 2 more2026-03-01📄 developmental biology